Pfizer is the world’s largest research-based biomedical and pharmaceutical company. The former Pfizer Ireland Pharmaceuticals site at Dun Laoghaire manufactured a range of diagnostic reagents and sterile pharmaceuticals. The plant was steadily expanded with the development of a 10,000sq ft sterile manufacturing facility. It was subsequently acquired by Amgen.

Callaghan Engineering provided the detailed engineering and tender packages for the upgrade of the steam and condensate systems, boiler house ventilation and new boiler controls which enabled significant improvements in operating efficiency.

Callaghan Engineering was also commissioned to undertake a front end study for the significant renovation and redevelopment of existing laboratories. This included a detailed project execution plan and cost report. The main challenge was to provide an effective and optimal facility layout, maximising the design space available to meet the requirements of new biologic laboratories. The design also had to consider proximity to process critical areas that lay outside of the laboratory perimeter. This  project execution plan provided a sound basis for detailed design work and the critical turnaround time.

Callaghan Engineering provided process and mechanical engineering services on a new Thermal Oxidiser installation.

CE also prepared an Explosion Protection Document (EPD) for the entire site and completed safety risk assessments for new product installations.

Callaghan Engineering have completed a number of projects at Leo in the range of €100,000 to €5,000,000.

Projects have varied from complete laboratory installations to solvent tank farms to packaging line installations.

Callaghan Engineering provided project management and multi-discipline engineering services on all projects.

Covidien, formerly Tyco Healthcare and now Medtronic, is a global healthcare company involved in the production and supply of medical devices, medical imaging products, medical supplies and pharmaceutical products.

Covidien retained Callaghan Engineering to provide process engineering services to develop the design for the refurbishment of a packaging room. A new high containment booth was recommended to meet the Occupational Exposure Limits (OEL) standards required including a complete room upgrade. Critical process utilities and process drainage were also upgraded to meet cGMP requirements.

The Covidien plant was later acquired by Mallinckrodt Pharmaceuticals.

Rice Steele identified a requirement to modify the mechanical services in a working Laboratory. The works involved included the strip out of existing temporary water and waste piping in the facility and the provision of a new natural gas supply to serve the refurbished area.

Additionally, the refurbished area was integrated with the existing hot and cold water services installation and supplied with pressurised cold water feed for a new drench shower.

The Laboratory upgrade was executed within the confines of a working facility with minimal disruption to the existing Laboratory and included full testing and commissioning of the extended facilities.